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The Powerpuff Girls (occasionally referred to as The Powerpuff Girls Classic to distinguish from the series reboot) is an American superhero animated television series created by animator Craig McCracken and produced by Hanna-Barbera (later Cartoon Network Studios) for Cartoon Network. The show follows Blossom, Bubbles, and Buttercup, three kindergarten-aged girls with superpowers, as well as their father and creator, a scientist named Professor Utonium. The girls all live in the fictional city of Townsville, USA, and are frequently called upon by the Mayor of Townsville to use their powers to help fight local criminals, including Mojo Jojo, Fuzzy Lumpkins, Him, and Princess Morebucks.

McCracken originally developed the show in 1992 as a cartoon short series entitled Whoopass Stew! while in his second year at CalArts. Following a name change, Cartoon Network featured the first Powerpuff Girls pilots in its animation showcase program What a Cartoon! in 1995 and 1996. The series made its official debut as a Cartoon Cartoon on November 18, 1998, with the final episode airing on March 25, 2005. Excluding the two pilot shorts, the series ran for a total of six seasons, totaling 78 episodes. Along with the episodes a Christmas special, and a feature film were also made concurrently. Two additional specials were made after the show ceased to air in 2005 which included a tenth anniversary special (2008), and a CGI special (2014) which was made without McCracken's input.

Various spin-off media include an anime, three CD soundtracks, a home video collection, comic books, a series of video games as well as various licensed merchandise. The series has been nominated for six Emmy Awards, nine Annie Awards, and a Kids' Choice Award during its run. In all, the series won four awards and generally received positive reception.

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